The Synthesis and Characterization of Mannich Bases Derived from Compounds
Özet
Aromatic heterocycles are very important motifs in medicinal chemistry researches. 1,3,4-oxadiazole
exhibit a wide range of biological activities [1]. 1,3,4-oxadiazole and their fused heterocyclic derivatives has attracted attention due to their biological importance[2,3].
In this work, various new compounds including ring 1,3,4-Oxadiazole were synthesized from the reactions of hydrazide compounds with carbon sulfur in basic medium. Mannich bases were prepared by tiyol tautomer form of 1,3,4-Oxadiazole (Scheme 1). Furthermore, structure-activity relationship was evaluated in respect to effect of different substitutions in newly synthesized 1,3,4-oxadiazole series. Then these compounds were characterized by performing of melting point, FT-IR, 1H-NMR (400 MHz), and 13C-NMR(100 MHz).
Koleksiyonlar
- Kimya [22]
DSpace@BİNGÖL by Bingöl University Institutional Repository is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 Unported License..