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Plantago major protective effects on antioxidant status after administration of 7,12-dimethylbenz(a)anthracene in rats

dc.contributor.authorOto, G. and Ekin, S. and Ozdemir, H. and Demir, H. and Yasar, S. and Levent, A. and Berber, I. and Kaki, B.
dc.date.accessioned2021-04-08T12:10:44Z
dc.date.available2021-04-08T12:10:44Z
dc.date.issued2011
dc.identifier.issn15137368
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-79958782513&partnerID=40&md5=e1859740eb9ffbb516d12c47ddc32a8b
dc.identifier.urihttp://acikerisim.bingol.edu.tr/handle/20.500.12898/5056
dc.description.abstractAim: The present study was designed to evaluate effects of Plantago major extract on oxidative status in Wistar albino rats administrated 7,12-dimethylbenz(a)anthracene (DMBA). Methods: Rats were divided into three equal groups of 6 animals each: Group 1 controls, group 2 treated with DMBA (100 mg/kg, single dose) and group 3 receiving the DMBA and the aqueous extract at 100 mg/kg/d for 60 days. Results: Significant decrease in catalase (P<0.05), carbonic anhydrase (p≤0.01), reduced glutathione (GSH) (P<0.01) and total protein (P<0.01) values was observed in the DMBA group compared with the healthy controls and DMBA + Plantago major groups. Conclusion: The results suggest preventive effects of Plantago major on DMBA induced oxidative damage in Wistar albino rats that might be due to decreased free radical generation.
dc.language.isoEnglish
dc.sourceAsian Pacific Journal of Cancer Prevention
dc.titlePlantago major protective effects on antioxidant status after administration of 7,12-dimethylbenz(a)anthracene in rats


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