The effect of CoQ10 and vitamin E on serum total sialic acid, lipid-bound sialic acid, some trace elements and minerals in rats induced with doxorubicin
Tarih
2011Yazar
Oto, G. and Ekin, S. and Yaşar, S. and Özdemir, H. and Yur, F.
Üst veri
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This study was designed to evaluate the effect of CoQ10 and vitamin E on serum total sialic acid (TSA), lipid bound sialic acid (LSA) and some elements in rat administered doxorubicin (DXR). Cu levels were increased in the group treated with DXR + vitamin E in comparison with DXR (p<0.05) and CoQ10 groups (p = 0.001). Furthermore, copper levels were increased in the group treated with DXR + CoQ10 in comparison with CoQ10 group (p < 0.05). Zn levels were decreased in the group treated with DXR + vitamin E in comparison with CoQ10 group (p < 0.05). Mg levels were decreased in subjects treated with DXR + vitamin E in comparison with the control group values (p < 0.05). Particularly, the observed increase in Cu levels in rats from DXR + vitamin E group might be due to the decrease of vitamin E. However, the oxidative damage could be as a result of DXR occurence and may be helpful to clinicians in chemotherapy using anthracycline. © 2011 Academic Journals.
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-79959336037&partnerID=40&md5=1366abb7a150f1b99dca18d3e0ba3b43http://acikerisim.bingol.edu.tr/handle/20.500.12898/5022
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