Show simple item record

Preventive effects of hesperidin on diabetic nephropathy induced by streptozotocin via modulating TGF-β1 and oxidative DNA damage

dc.contributor.authorKandemir, F.M. and Ozkaraca, M. and Küçükler, S. and Caglayan, C. and Hanedan, B.
dc.date.accessioned2021-04-08T12:07:16Z
dc.date.available2021-04-08T12:07:16Z
dc.date.issued2018
dc.identifier10.1080/15569543.2017.1364268
dc.identifier.issn15569543
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85027843932&doi=10.1080%2f15569543.2017.1364268&partnerID=40&md5=8cfa760e3d32f89a1054377ae49eec0d
dc.identifier.urihttp://acikerisim.bingol.edu.tr/handle/20.500.12898/4274
dc.description.abstractHesperidin (HSP) is a natural bioflavonoid with active pharmacological properties. This study was conducted to investigate the hypoglycemic and antioxidant effects of HSP on streptozotocin-induced diabetic nephropathy in rats. Serum urea, creatinine and malondialdehyde levels increased in the diabetic group, while antioxidant enzyme activities decreased compared to the control group. Moreover, transforming growth factor-beta 1 level, 8-hydroxy-2′-deoxyguanosine expression and histopathological changes in renal tissue were increased in the diabetic group. On the other hand, HSP therapy significantly regulated these values in diabetic rats. Our results indicated that HSP might be helpful to protect diabetic nephropathy. © 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group.
dc.language.isoEnglish
dc.sourceToxin Reviews
dc.titlePreventive effects of hesperidin on diabetic nephropathy induced by streptozotocin via modulating TGF-β1 and oxidative DNA damage


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record