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Palliative effect of curcumin on doxorubicin-induced testicular damage in male rats

dc.contributor.authorAksu, E.H. and Kandemir, F.M. and Yıldırım, S. and Küçükler, S. and Dörtbudak, M.B. and Çağlayan, C. and Benzer, F.
dc.date.accessioned2021-04-08T12:06:45Z
dc.date.available2021-04-08T12:06:45Z
dc.date.issued2019
dc.identifier10.1002/jbt.22384
dc.identifier.issn10956670
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85071356423&doi=10.1002%2fjbt.22384&partnerID=40&md5=44b49df790989fa505243874058c3f03
dc.identifier.urihttp://acikerisim.bingol.edu.tr/handle/20.500.12898/4061
dc.description.abstractThis study aimed to investigate the effect of curcumin (CUR) on doxorubicin (DOX)-induced testicular damage in male rats. Thirty-five adult male Wistar rats were used. Control group was received saline for 7 days. CUR group received CUR for 7 days. DOX group received single dose DOX on the 5th day. DOX+ CUR-100 group received 100 mg/kg/day CUR for 7 days and DOX injection on the 5th day. DOX + CUR-200 group received 200 mg/kg/day CUR for 7 days and DOX injection on the 5th day. DOX treatment decreased in sperm motility rate, live sperm percentages, cellular antioxidants, and increased malondialdehyde (MDA) levels, necrosis, degenerations, and slimming in seminiferous tubules, and DNA damages in testes by inducing oxidative stress. CUR treatment mitigated significantly these side effects when compared with DOX group in a dose-dependent manner. In conclusion, CUR treatment can be used in the mitigation of DOX-induced testicular toxicity. © 2019 Wiley Periodicals, Inc.
dc.language.isoEnglish
dc.sourceJournal of Biochemical and Molecular Toxicology
dc.titlePalliative effect of curcumin on doxorubicin-induced testicular damage in male rats


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