Plantago major Protective Effects on Antioxidant Status after
Administration of 7,12-Dimethylbenz(a)anthracene in Rats

dc.contributor.author	Oto, Gokhan and Ekin, Suat and Ozdemir, Hulya and Demir, Halit and Yasar, Semih and Levent, Abdulkadir and Berber, Ismet and Kaki, Baris
dc.date.accessioned	2021-04-02T12:03:54Z
dc.date.available	2021-04-02T12:03:54Z
dc.date.issued	2011
dc.identifier.issn	1513-7368
dc.identifier.uri	http://acikerisim.bingol.edu.tr/handle/20.500.12898/2625
dc.description.abstract	Aim: The present study was designed to evaluate effects of Plantago major extract on oxidative status in Wistar albino rats administrated 7,12-dimethylbenz(a)anthracene (DMBA). Methods: Rats were divided into three equal groups of 6 animals each: Group 1 controls, group 2 treated with DMBA (100 mg/kg, single dose) and group 3 receiving the DMBA and the aqueous extract at 100 mg/kg/d for 60 days. Results: Significant decrease in catalase (P<0.05), carbonic anhydrase (p <= 0.01), reduced glutathione (GSH) (P<0.01) and total protein (P<0.01) values was observed in the DMBA group compared with the healthy controls and DMBA + Plantago major groups. Conclusion: The results suggest preventive effects of Plantago major on DMBA induced oxidative damage in Wistar albino rats that might be due to decreased free radical generation.
dc.language.iso	English
dc.source	ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
dc.title	Plantago major Protective Effects on Antioxidant Status after Administration of 7,12-Dimethylbenz(a)anthracene in Rats
dc.type	Article

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