WOS İndeksli Yayınlar Koleksiyonu

The Effects of Ellagic Acid on Some Biochemical Parameters in the Liver of Rats Against Oxidative Stress Induced by Aluminum

Fri, 01 Jan 2010 00:00:00 GMT

The Effects of Ellagic Acid on Some Biochemical Parameters in the Liver of Rats Against Oxidative Stress Induced by Aluminum Ozkaya, Ahmet and Celik, Sait and Yuce, Abdurrauf and Sahin, Zafer and Yilmaz, Okkes Antioxidant, anti-inflammatory and anti-carcinogenic effects having Ellagic acid ( 2,3,7,8-tetrahidroksil {[}1] benzapiranol {[}5,4,3-CDE] {[}1] benzopiran-5, 10-dione) pomegranate, raspberry, strawberry, many fruits such as grapes and walnuts grained derivative is a substance found in vegetable polyphenols. Aluminum is known to cause toxic effects on variety organ systems. In this study, the effect of ellagic acid on the liver of rats against oxidative stress induced by aluminum chloride (AlCl3) was investigated. Adult male Sprague-dawley rats were randomly divided in four groups. Control the first group, the second group Ellagic acid group, the third group AlCl3 group, the fourth group was used as AlCl3 + Ellagic acid. Ellagic acid 12 mg/kg dose with the orogastric probe and AlCl3 8.3 mg/kg intraperitoneal was administered as a 55 days every other day. Glutathione (GSH) in the liver, malondialdehyde (MDA), vitamin E levels and glutathione peroxidase (GSH-Px) and catalase ( CAT) activities were determined. While administration of AlCl3 increased the MDA level and CAT activity, it decreased the GSH-Px activity in liver compared those of the control group. The effect of ellagic acid to AlCl3-treated rats decreased the MDA levels and increased GSH, GSH-Px and CAT activities in these samples. According to the data we obtained, a result AlCl3 application against oxidative damage in the liver, which has the potential protective effect of ellagic acid, can be said.

Effect of Lipoic Acid on the Some Elements in Brain Tissue of DMBA-Induced Guinea Pigs

Thu, 01 Jan 2009 00:00:00 GMT

Effect of Lipoic Acid on the Some Elements in Brain Tissue of DMBA-Induced Guinea Pigs Ciftci, Harun and Oezkaya, Ahmet and Dayangac, Alpaslan and Oelcuecue, Ali and Celik, Sait and Sahin, Zafer and Ates, Sema The oxidative stress, depending on many factors in the etiology of developing cancer caused by reactive oxygen species, plays an important role. In our study, 7, 12-dimethylbenz-{[}a]anthracene (DMBA) was applied in Guinea Pigs, the alpha lipoic acid (alpha-LA) has antioxidant properties was investigated protective role against to levels of macro and trace elements in brain In experiments: totally 24 adult male Guinea Pigs were randomly divided into 4 equal groups (control, DMBA, alpha-LA and DMBA+alpha-LA) containing same numbers. As a result of the analysis in Guinea Pigs brain with the aid of ICP-AES: it was found that the level of calcium from macro elements in DMBA group increased according to control group (P < 0.01) and decreased in DMBA+alpha-LA group (P < 0.01). that was in the same levels with control group Magnesium decreased in DMBA group according to control group (P < 0.01) and DMBA+alpha-LA group and increased in close level of control group. Regarding trace elements, it was seemed that copper levels compared with the control group decreased in DMBA group (P < 0.01) and DMBA+alpha-LA group, it was same level with control group. It was observed that the level zinc decreased according to control group in DMBA group (P < 0.01) and increased in DMBA+alpha-LA group (P < 0.01). In addition, it was obtained that levels of iron and manganese in between groups were not significant (P > 0.05). As a result, it can be said that from the point of macro and trace elements, the lipoic acid (alpha-LA) was indicated neuroprotective effect for protection of important organs such as brain from the oxidative stress.

Effects of Nitrogen and Phosphorus Fertilization on Micro Nutrient Contents of Trifolium angustifolium and Lotus suaveolens from Fabaceae on a Grassland Ecosystem: the Case of Kahramanmaras, Eastern Mediterranean Region of Turkey

Fri, 01 Jan 2010 00:00:00 GMT

Effects of Nitrogen and Phosphorus Fertilization on Micro Nutrient Contents of Trifolium angustifolium and Lotus suaveolens from Fabaceae on a Grassland Ecosystem: the Case of Kahramanmaras, Eastern Mediterranean Region of Turkey Demirkiran, A. R. and Uslu, O. S. This study examined the effectiveness of various grass plants as Trifolium angustifolium and Lotus suaveolens from Fabaceae to fertilizer treatments (N+P fertilization) to encourage the micro nutrition of this vegetation. Micro nutrient contents of this vegetation were determined annually in 2002 and 2003. Experimental plots received rains of 606.3 and 857.5 mm during the 2 study years compared to mean growing season rainfall of 729.8 mm. Micro nutrient contents of these grass plants were increased significantly by nitrogen and phosphorus fertilizers application. Contents of micro nutrients after nitrogen and phosphorus fertilizer treatments, it is determined and ordered for Lotus suaveolens Cu>Fe>Zn>Mn and for Trifolium angustifolium Cu>Fe = Mn>Zn. Nitrogen and phosphorus chemical fertilizers influence both micro nutrient mobility and bioavailability and the effects to these plants may be different.

Experimental and Theoretical Investigation of the Molecular and Electronic Structure of N-Cyclohexyl-2-{[}5-(4-pyridyl)-4-(p-tolyl)-4H-1,2,4-tria-zol-3-ylsulfan yl]acetamide Dihydrate

Thu, 01 Jan 2009 00:00:00 GMT

Experimental and Theoretical Investigation of the Molecular and Electronic Structure of N-Cyclohexyl-2-{[}5-(4-pyridyl)-4-(p-tolyl)-4H-1,2,4-tria-zol-3-ylsulfan yl]acetamide Dihydrate Dincer, Muharrem and Ozdemir, Namik and Cetin, Ahmet and Keser, Tekin