Synthesis and antioxidant properties of novel thiosemicarbazide derivatives

dc.contributor.author	Çetin, Ahmet
dc.date.accessioned	2016-06-03T06:43:54Z
dc.date.available	2016-06-03T06:43:54Z
dc.date.issued	2016-05-23
dc.identifier.uri	http://acikerisim.bingol.edu.tr/handle/20.500.12898/816
dc.description.abstract	Novel derivatives of thiosemicarbazide were synthesized and evaluated for their antioxidant properties. Starting from readily available pyridine-2,5-dicarboxylic acid the title compounds were prepared. The reaction of carboxylic acid with absolute ethanol afforded the corresponding diethyl pyridine-2,5-dicarboxylate. The reaction of compound 1 with hydrazine hydrate good yielded pyridine-2,5-dicarbohydrazide. Refluxing compound 2 with alkyl/aryl isothiocyanate for 3-8 h afforded 1,4-disubstituted thiosemicarbazides in good yield (75-90%). The final compounds showed very high activity (88.16-71.34%) against 2,2-diphenyl-1-picrylhydrazyl free radical at the concentration of 25 μg/mL while the others showed lower activity.	tr_TR
dc.language.iso	eng	tr_TR
dc.publisher	2 nd International Conference on Organic Electronic Material Technologies (OEMT2016)	tr_TR
dc.subject	1,2,4-triazoles, thiosemicarbazides, antioxidant activity, reducing power	tr_TR
dc.title	Synthesis and antioxidant properties of novel thiosemicarbazide derivatives	tr_TR
dc.type	Presentation	tr_TR