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dc.contributor.authorAcik, M.N. and Karahan, M. and Ongor, H. and Karagulle, B. and Cetinkaya, B.
dc.date.accessioned2021-04-08T12:09:46Z
dc.date.available2021-04-08T12:09:46Z
dc.date.issued2013
dc.identifier.issn00351555
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84877269231&partnerID=40&md5=853728646fbed76d04a65ba3819ef023
dc.identifier.urihttp://acikerisim.bingol.edu.tr/handle/20.500.12898/4902
dc.description.abstractThe prevalence of virulence and cytolethal distending toxin (Cdt) genes was investigated in isolates of Campylobacter jejuni, C. coli, C. lanienae and C. lari originated from intestinal contents and gall bladders of clinically healthy cattle. In this study the presence of 10 pathogenic genes responsible for the expression of adherence, invasion, colonization and cytotoxin production was examined in 210 Campylobacter species (194 C. jejuni, 12 C.coli, 3 C. lari, one C. lanienae) isolated from cattle intestinal content and gall bladder. In addition, Campylobacter isolates were investigated for production of functional cytolethal distending toxin (cdt) using HeLa cell culture. The presence of flaA (100%), cadF (96.7%), virB11(14.8%), pldA(39%), ciaB(30), dnaJ (61%), racR (63.8%), cdtA (70.5%), cdtb (70.9%) and cdtC (71.9%) genes was detected in Campylobacter species by PCR. Only three Campylobacter strains produced cytolethal distending toxin in a HeLa cell assay. These data suggest that all 10 virulence genes are widespread among Campylobacter isolates, but that capacity of cdt production are low in HeLa cell culture. To the authors'knowledge, this is the first study which reports the presence of virulence and toxin genes in C. lanienae isolated from cattle in the world. Copyright © Revue Méd. Vét., 2013.
dc.language.isoEnglish
dc.sourceRevue de Medecine Veterinaire
dc.titleInvestigation of cytolethal distending toxin production and virulence genes in Campylobacter isolates from cattle


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