A bis-Lewis basic 2-aminoDMAP/prolinamide organocatalyst for application to the enantioselective synthesis of Warfarin and derivatives

dc.contributor.author	Işik, M. and Akkoca, H.U. and Akhmedov, I.M. and Tanyeli, C.
dc.date.accessioned	2021-04-08T12:08:33Z
dc.date.available	2021-04-08T12:08:33Z
dc.date.issued	2016
dc.identifier	10.1016/j.tetasy.2016.04.001
dc.identifier.issn	09574166
dc.identifier.uri	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84963976996&doi=10.1016%2fj.tetasy.2016.04.001&partnerID=40&md5=2524d9aa49fddbf7d3e2ec6934c71050
dc.identifier.uri	http://acikerisim.bingol.edu.tr/handle/20.500.12898/4639
dc.description.abstract	A new chiral sec-amine/amidine-base hybrid catalyst, 2-aminoDMAP/prolinamide, is reported, which is able to catalyze conjugate addition of 4-hydroxycoumarin and various benzylideneacetones, a reaction that directly gives anticoagulant Warfarin and its analogues, with good yields (70-87%) and enantioselectivities (58-72%). © 2016 Elsevier Ltd.
dc.language.iso	English
dc.source	Tetrahedron Asymmetry
dc.title	A bis-Lewis basic 2-aminoDMAP/prolinamide organocatalyst for application to the enantioselective synthesis of Warfarin and derivatives

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