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dc.contributor.authorGecibesler, I.H. and Aydin, M.
dc.date.accessioned2021-04-08T12:06:29Z
dc.date.available2021-04-08T12:06:29Z
dc.date.issued2020
dc.identifier10.1590/0001-3765202020190819
dc.identifier.issn00013765
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85086052317&doi=10.1590%2f0001-3765202020190819&partnerID=40&md5=f80af0bde98610bd7b369d4c317c560c
dc.identifier.urihttp://acikerisim.bingol.edu.tr/handle/20.500.12898/3958
dc.description.abstractHerbal-flavonoids (HF) as polyphenolic secondary metabolites are taken in the daily diet to join in many metabolic processes in the human organism. Anti-proliferative activities and human serum albumin (HSA) binding capacities of herbal-flavonoids namely 7,5’-dimethoxyisoetin (HF1), homoorientin-6’’-4-O-methyl-myo-inositol (HF2), (2R, 3R)-(+)-dihydrokaempferol-7,4’-dimethylether (HF3), eriodictyol-7,4’-dimethylether (HF4) and flavonoids isoorientin (HF5) and genkwanin (HF6) were investigated. Antiproliferative activities were determined by the xCELLigence system by treatment with human prostate (PC3) and cervical cancer (HeLa) cells. The binding capacities were studied by two-dimensional (2D-FL) and three-dimensional (3D-FL) fluorescence spectroscopy. HeLa and PC3 cell lines were treated with flavonoids at 10, 50 and 100 μg/mL concentrations over a 48 hour period. Stable anti-proliferative efficacy plots were obtained for tested flavonoids. From the flavonoids, HF3 and HF4 showed the strongest anti-proliferative effect against PC3 and HeLa cell line. HF1 and HF2 exhibited the strongest binding capacity to the HSA corresponding to Kb values of 3.81 x 104 M-1 and 6.00 x 104 M-1, respectively. The studies revealed that the flavonoids form the basis of in vivo preclinical studies as important nutraceuticals of the daily diet, as well as modelled in medical and pharmacological applications. © 2020, Academia Brasileira de Ciencias. All rights reserved.
dc.language.isoEnglish
dc.sourceAnais da Academia Brasileira de Ciencias
dc.titlePlasma protein binding of herbal-flavonoids to human serum albumin and their anti-proliferative activities


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