The Effects of Ellagic Acid on Some Biochemical Parameters in the Liver of Rats Against Oxidative Stress Induced by Aluminum
Tarih
2010Yazar
Ozkaya, Ahmet and Celik, Sait and Yuce, Abdurrauf and Sahin, Zafer and
Yilmaz, Okkes
Üst veri
Tüm öğe kaydını gösterÖzet
Antioxidant, anti-inflammatory and anti-carcinogenic effects having
Ellagic acid ( 2,3,7,8-tetrahidroksil {[}1] benzapiranol {[}5,4,3-CDE]
{[}1] benzopiran-5, 10-dione) pomegranate, raspberry, strawberry, many
fruits such as grapes and walnuts grained derivative is a substance
found in vegetable polyphenols. Aluminum is known to cause toxic effects
on variety organ systems. In this study, the effect of ellagic acid on
the liver of rats against oxidative stress induced by aluminum chloride
(AlCl3) was investigated. Adult male Sprague-dawley rats were randomly
divided in four groups. Control the first group, the second group
Ellagic acid group, the third group AlCl3 group, the fourth group was
used as AlCl3 + Ellagic acid. Ellagic acid 12 mg/kg dose with the
orogastric probe and AlCl3 8.3 mg/kg intraperitoneal was administered as
a 55 days every other day. Glutathione (GSH) in the liver,
malondialdehyde (MDA), vitamin E levels and glutathione peroxidase
(GSH-Px) and catalase ( CAT) activities were determined. While
administration of AlCl3 increased the MDA level and CAT activity, it
decreased the GSH-Px activity in liver compared those of the control
group. The effect of ellagic acid to AlCl3-treated rats decreased the
MDA levels and increased GSH, GSH-Px and CAT activities in these
samples. According to the data we obtained, a result AlCl3 application
against oxidative damage in the liver, which has the potential
protective effect of ellagic acid, can be said.
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