Designing an Intracellular Fluorescent Probe for Glutathione: Two Modulation Sites for Selective Signal Transduction
Date
2014Author
Isik, Murat and Guliyev, Ruslan and Kolemen, Safacan and Altay, Yigit
and Senturk, Berna and Tekinay, Turgay and Akkaya, Engin U.
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Show full item recordAbstract
A selective probe for glutathione was designed and synthesized. The
design incorporates spatial and photophysical constraints for the
maximal emission signal. Thus, pHs, as well as the intracellular thiol
concentrations, determine the emission signal intensity through a tight
control of charge-transfer and PeT processes. The probe works
satisfactorily inside the human breast adenocarcinoma cells,
highlighting GSH distribution in the cytosol.
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