Vertebrate insulin alters the expression profile of steroid hormone ecdysone receptor complex components and autophagy-related genes in the pupal fat body of the silkworm, Bombyx mori
Abstract
Various studies have shown that the insulin-like peptides present in
insects and investigation of their possible effects on insect physiology
have significance for clarifying the evolutionary developmental period
of insulin. The insect fat body is an organ analog to vertebrate adipose
tissue and liver. In insects which do not have feeding activity during
pupal and adult stages such as Bombyx mori, substances and energy
required for continuation of life and development of tissues and organs
are provided by the fat body via the autophagy process. In this study,
we aimed to analyze the action of mammalian insulin in Bombyx pupae by
studying its effects on physiological parameters, and the transcript
levels of both ecdysone receptors and autophagy-related genes Atg8 and
Atg 12. Our results showed that the biochemical contents of the Bombyx
mori fat body and the expression of genes related to autophagy and
ecdysone receptor complex elements responded differently to insulin
treatment depending on the application time.
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