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Protective effect of chrysin on cyclophosphamide-induced hepatotoxicity and nephrotoxicity via the inhibition of oxidative stress, inflammation, and apoptosis

Temel, Y. and Kucukler, S. and Yıldırım, S. and Caglayan, C. and Kandemir, F.M. (2020)

Cyclophosphamide (CYP) is a chemotherapeutic agent used in the treatment of autoimmune disorders and malignant diseases. However, its usage is restricted due to its severe side effects, especially hepatotoxicity and ...

Protective Effect of Hesperidin on Sodium Arsenite-Induced Nephrotoxicity and Hepatotoxicity in Rats

Turk, E. and Kandemir, F.M. and Yildirim, S. and Caglayan, C. and Kucukler, S. and Kuzu, M. (2019)

The present study was conducted to investigate the protective effects of hesperidin (HSP) against sodium arsenite (SA)-induced nephrotoxicity and hepatotoxicity in rats. Thirty-five male Sprague Dawley rats were divided ...

Protective effect of morin on doxorubicin-induced hepatorenal toxicity in rats

Kuzu, M. and Yıldırım, S. and Kandemir, F.M. and Küçükler, S. and Çağlayan, C. and Türk, E. and Dörtbudak, M.B. (2019)

Although Doxorubicin (DOX) is a widespread drug used in the treatment of cancer, its clinical use is restricted due to its common side effects. In addition, administrating DOX with an antioxidant has recently become a new ...

Protective effect of rutin on mercuric chloride-induced reproductive damage in male rats

Kandemir, F.M. and Caglayan, C. and Aksu, E.H. and Yildirim, S. and Kucukler, S. and Gur, C. and Eser, G. (2020)

This study investigated the effects of rutin against reproductive damage caused by toxic mercury in male rats. Thirty-five Sprague Dawley rats were used. Control group was injected with saline for 7 days. The rutin-100 ...

Protective effect of sildenafil citrate on contralateral testis injury after unilateral testicular torsion/detorsion

Yildiz, Hamit and Durmus, Ali Said and Simsek, Halil and Yaman, Mine (2011)

OBJECTIVES: This study was designed to investigate prevention of contralateral testicular injury with sildenafil citrate after unilateral testicular torsion/detorsion. METHODS: Thirty-seven adult male rats were divided ...

Protective Effects of Chrysin Against Oxidative Stress and Inflammation Induced by Lead Acetate in Rat Kidneys: a Biochemical and Histopathological Approach

Kucukler, S. and Benzer, F. and Yildirim, S. and Gur, C. and Kandemir, F.M. and Bengu, A.S. and Ayna, A. and Caglayan, C. and Dortbudak, M.B. (2021)

In this study, the protective effects of chrysin (CR) on lead acetate (PbAc)-induced renal toxicity in Sprague-Dawley rats were investigated with biochemical, histopathological, and immunohistochemical methods. In the ...

Protective Effects of Curcumin Against Paclitaxel-Induced Spinal Cord and Sciatic Nerve Injuries in Rats

Yardım, A. and Kandemir, F.M. and Çomaklı, S. and Özdemir, S. and Caglayan, C. and Kucukler, S. and Çelik, H. (2021)

Paclitaxel (PTX) is an antineoplastic agent commonly used in the treatment of solid tumors and is known to cause dose-limiting peripheral neurotoxicity. This study was performed to evaluate the protective effect of curcumin ...

Protective effects of gallic acid on doxorubicin-induced cardiotoxicity; an experimantal study

Ekinci Akdemir, F.N. and Yildirim, S. and Kandemir, F.M. and Tanyeli, A. and Küçükler, S. and Bahaeddin Dortbudak, M. (2019)

The present study aims to examine the possible beneficial effects of gallic acid (GA) against doxorubicin-induced cardiotoxicity in the experimental model. Rats were weighed and divided into groups. Groups as following; ...

Protective effects of nanostructures of hydrated C60 fullerene on reproductive function in streptozotocin-diabetic male rats

Bal, R. and Türk, G. and Tuzcu, M. and Yilmaz, O. and Ozercan, I. and Kuloglu, T. and Gür, S. and Nedzvetsky, V.S. and Tykhomyrov, A.A. and Andrievsky, G.V. and Baydas, G. and Naziroglu, M. (2011)

Diabetes mellitus is a well-recognized cause of male sexual dysfunction and impairments of male fertility. Streptozotocin (STZ) is used for medical treatment of neoplastic islet β-cells of pancreas and producing of animal ...

Protective effects of zingerone on cisplatin-induced nephrotoxicity in female rats

Kandemir, F.M. and Yildirim, S. and Caglayan, C. and Kucukler, S. and Eser, G. (2019)

Zingerone (ZO), one of the active components of ginger (Zingiber officinale), is a phenolic alkanone with antioxidant, antiapoptotic, and anti-inflammatory properties. Cisplatin (CP) is a widely used chemotherapeutic drug ...

Psephellus vanensis (Asteraceae), a new species from east Turkey

Dogan, Bekir and Behcet, Lutfi and Duran, Ahmet and Avlamaz, Davut (2015)

A new species, Psephellus vanensis A.Duran, Behcet \& B.Dogan (Asteraceae) from Anatolia, Turkey, is described and illustrated. The species grows on the serpentine stony field of the village of caldiran in the district of ...

Psephellus vanensis (Asteraceae), a new species from east Turkey

Dogan, B. and Behçet, L. and Duran, A. and Avlamaz, D. (2015)

A new species, Psephellus vanensis A.Duran, Behçet & B.Dogan (Asteraceae) from Anatolia, Turkey, is described and illustrated. The species grows on the serpentine stony field of the village of Çaldi{dotless}ran in the ...

Pseudophleum anatolicum, a New Endemic Species of Pseudophleum (Poaceae) from East Anatolia, Turkey

Doʇan, M. and Behçet, L. and Sinan, A. (2015)

Pseudophleum anatolicum (Poaceae: Poeae), a new species collected from Bingöl Province in East Anatolia, Turkey, is described and illustrated as the second species of the genus ever discovered. The new species is distinguished ...

Puri cation and characterization of mitochondrial thioredoxin reductase enzymefrom rainbow trout (Oncorhynchus mykiss) liver and investigation of the in vitroeffects of some metal ions on the enzyme

İlknur ÖZGENÇLİ and MEHMET ÇİFTCİ (2016)

Purification and biochemical characterization of glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and glutathione reductase from rat lung and inhibition effects of some antibiotics

Adem, Sevki and Ciftci, Mehmet (2016)

G6PD, 6PGD and GR have been purified separately in the single step from rat lung using 20, 5'-ADP Sepharose 4B affinity chromatography. The purified enzymes showed a single band on sodium dodecyl sulfate polyacrylamide gel ...

Purification and biochemical characterization of glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and glutathione reductase from rat lung and inhibition effects of some antibiotics

Adem, S. and Ciftci, M. (2016)

G6PD, 6PGD and GR have been purified separately in the single step from rat lung using 2′, 5′-ADP Sepharose 4B affinity chromatography. The purified enzymes showed a single band on sodium dodecyl sulfate polyacrylamide gel ...

Purification and characterization glutathione S-transferase enzyme from japanese quail (Coturnix coturnix Japonica) heart

Ahmed, Barzan Mirza (Bingol University, Institute of Sciences, 2018)

In this study glutathione S-transferase enzyme (EC: 2.5.1.18) from the heart of Japanese quail was purified with 34.0 EU/mg specific activity, 10.44% purification yield and 78.29 purification folds and characterized. Firstly ...

Purification and characterization glutathione S-transferase enzyme from quail (Coturnix, coturnix japonica) heart and investigation the effect of some metal ions on enzyme activity

Barzan Mirza AHMED and YUSUF TEMEL and MEHMET ÇİFTCİ (2019)

Purification and Characterization of Glucose 6-Phosphate Dehydrogenase, 6-Phosphogluconate Dehydrogenase, and Glutathione Reductase from Rat Heart and Inhibition Effects of Furosemide, Digoxin, and Dopamine on the Enzymes Activities

Adem, S. and Ciftci, M. (2016)

The present study was aimed to investigate characterization and purification of glucose–6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and glutathione reductase from rat heart and the inhibitory effect of ...

Purification and characterization of mitochondrial thioredoxin reductase enzyme from rainbow trout (Oncorhynchus mykiss) liver and investigation of the in vitro effects of some metal ions on the enzyme

Ozgencli, Ilknur and Ciftci, Mehmet (2016)

Thioredoxin reductase (E.C 1.6.4.5.; TrxR) is an enzyme belonging to the flavoprotein family of pyridine nucleotide-disulfide oxidoreductases. In this study, mitochondrial TrxR enzyme was purified from rainbow trout mitochondria. ...