Effect of lipoic acid on the some elements in brain tissue of DMBA-induced Guinea Pigs [DMBA i̇le i̇ndüklenmiş kobayların beyin dokusundaki bazı elementler üzerine alfa lipoik asidin etkisi]

Abstract

The oxidative stress, depending on many factors in the etiology of developing cancer caused by reactive oxygen species, plays an important role. In our study, 7, 12-dimethylbenz-[a]anthracene (DMBA) was applied in Guinea Pigs, the alpha lipoic acid (α-LA) has antioxidant properties was investigated protective role against to levels of macro and trace elements in brain. In experiments; totally 24 adult male Guinea Pigs were randomly divided into 4 equal groups (control, DMBA, α-LA and DMBA+α-LA) containing same numbers. As a result of the analysis in Guinea Pigs brain with the aid of ICP-AES; it was found that the level of calcium from macro elements in DMBA group increased according to control group (P<0.01) and decreased in DMBA+α-LA group (P<0.01), that was in the same levels with control group. Magnesium decreased in DMBA group according to control group (P<0.01) and DMBA+α-LA group and increased in close level of control group. Regarding trace elements, it was seemed that copper levels compared with the control group decreased in DMBA group (P<0.01) and DMBA+α-LA group, it was same level with control group. It was observed that the level zinc decreased according to control group in DMBA group (P<0.01) and increased in DMBA+α-LA group (P<0.01). In addition, it was obtained that levels of iron and manganese in between groups were not significant (P>0.05). As a result, it can be said that from the point of macro and trace elements, the lipoic acid (α-LA) was indicated neuroprotective effect for protection of important organs such as brain from the oxidative stress.