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dc.contributor.authorBal, R. and Naziroǧlu, M. and Türk, G. and Yilmaz, O. and Kuloǧlu, T. and Etem, E. and Baydas, G.
dc.date.accessioned2021-04-08T12:10:03Z
dc.date.available2021-04-08T12:10:03Z
dc.date.issued2012
dc.identifier10.1002/cbf.2826
dc.identifier.issn02636484
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84865399047&doi=10.1002%2fcbf.2826&partnerID=40&md5=63ccdd39b52f8f3049cfe01c0e507f87
dc.identifier.urihttp://acikerisim.bingol.edu.tr/handle/20.500.12898/4948
dc.description.abstractWe investigated whether treatment with imidacloprid would induce morphological changes, DNA fragmentation, antioxidant imbalance and apoptosis in the reproductive system of developing male rats. Twenty-four male rats were included in this 90-day study, starting at 7days of age. The rats were divided into four groups. The first group was used as control. The second, third and fourth groups received oral 0.5-, 2- and 8-mg/kg imidacloprid, respectively. Serum, sperm and testis samples were collected from all groups at the end of the experimental period. The weights of the epididymis, vesicula seminalis, epididymal sperm concentration, body weight gain, testosterone and reduced glutathione values were lower in the imidacloprid-treated groups than that in the controls. All treated groups had increased lipid peroxidation, fatty acid concentrations and higher rates of abnormal sperm. Apoptosis and fragmentation of seminal DNA were higher in rats treated at the two higher doses of imidacloprid. These results show that this compound has a negative effect on sperm and testis of rats. © 2012 John Wiley & Sons, Ltd.
dc.language.isoEnglish
dc.sourceCell Biochemistry and Function
dc.titleInsecticide imidacloprid induces morphological and DNA damage through oxidative toxicity on the reproductive organs of developing male rats


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