Designing an intracellular fluorescent probe for glutathione: Two modulation sites for selective signal transduction

dc.contributor.author	Işik, M. and Guliyev, R. and Kolemen, S. and Altay, Y. and Senturk, B. and Tekinay, T. and Akkaya, E.U.
dc.date.accessioned	2021-04-08T12:09:27Z
dc.date.available	2021-04-08T12:09:27Z
dc.date.issued	2014
dc.identifier	10.1021/ol501272z
dc.identifier.issn	15237060
dc.identifier.uri	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84903181899&doi=10.1021%2fol501272z&partnerID=40&md5=cb96b417a3f451640db4b072c48d6c85
dc.identifier.uri	http://acikerisim.bingol.edu.tr/handle/20.500.12898/4835
dc.description.abstract	A selective probe for glutathione was designed and synthesized. The design incorporates spatial and photophysical constraints for the maximal emission signal. Thus, pHs, as well as the intracellular thiol concentrations, determine the emission signal intensity through a tight control of charge-transfer and PeT processes. The probe works satisfactorily inside the human breast adenocarcinoma cells, highlighting GSH distribution in the cytosol. © 2014 American Chemical Society.
dc.language.iso	English
dc.source	Organic Letters
dc.title	Designing an intracellular fluorescent probe for glutathione: Two modulation sites for selective signal transduction

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