Designing an intracellular fluorescent probe for glutathione: Two modulation sites for selective signal transduction

Thumbnail
Date
2014
Author
Işik, M. and Guliyev, R. and Kolemen, S. and Altay, Y. and Senturk, B. and Tekinay, T. and Akkaya, E.U.
Metadata
Show full item record
Abstract
A selective probe for glutathione was designed and synthesized. The design incorporates spatial and photophysical constraints for the maximal emission signal. Thus, pHs, as well as the intracellular thiol concentrations, determine the emission signal intensity through a tight control of charge-transfer and PeT processes. The probe works satisfactorily inside the human breast adenocarcinoma cells, highlighting GSH distribution in the cytosol. © 2014 American Chemical Society.
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84903181899&doi=10.1021%2fol501272z&partnerID=40&md5=cb96b417a3f451640db4b072c48d6c85
http://acikerisim.bingol.edu.tr/handle/20.500.12898/4835
Collections