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dc.contributor.authorDalar, A. and Guo, Y. and Esim, N. and Bengu, A.S. and Konczak, I.
dc.date.accessioned2021-04-08T12:09:01Z
dc.date.available2021-04-08T12:09:01Z
dc.date.issued2015
dc.identifier10.1016/j.hermed.2015.02.001
dc.identifier.issn22108033
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84931564366&doi=10.1016%2fj.hermed.2015.02.001&partnerID=40&md5=2942f574701aee28d2fcae712d15eac3
dc.identifier.urihttp://acikerisim.bingol.edu.tr/handle/20.500.12898/4748
dc.description.abstractAbstract Phytochemical composition and potential health attributes of Dactylorhiza chuhensis Renz&Taub., an endemic orchid from Eastern Anatolia, were investigated. Lyophilized methanol-based extracts obtained from leaf, flower, stem and tuber were investigated for the presence of phenolic compounds [Folin-Ciocalteu assay and high performance liquid chromatography analysis (HPLC)], antioxidant capacities [ferric reducing antioxidant power (FRAP) and oxygen radical absorbance capacity (ORAC) assay] and enzyme-inhibitory activities [lipase, α-amylase, α-glucosidase and angiotensin converting enzyme (ACE)]. The tuber, used as a traditional remedy and utilized by the pharmaceutical industry, had the lowest content of total phenolics, inferior antioxidant and enzyme-inhibitory activities. The highest phenolic content (44.9 ± 0.8 mg GAE/g DW) was exhibited by the leaf extract, which also showed superior reducing (736.8 ± 16.2 μmol Fe2+/g DW) and oxygen radical scavenging capacities (2715.8 ± 83.5 μmol Trolox E/g DW). The inhibitory activities of the leaf extract toward α-amylase, α-glucosidase and ACE were moderate. Applied at non-toxic concentrations, the leaf extract effectively reduced accumulation of nitric oxide (NO) in lipopolysaccharide (LPS)-activated hepatocellular carcinoma (HepG2) cells. Further studies towards potential utilization of D. chuhensis leaf as a source of physiologically active phytochemcials are justified. Crown Copyright © 2015 Published by Elsevier GmbH.
dc.language.isoEnglish
dc.sourceJournal of Herbal Medicine
dc.titleHealth attributes of an endemic orchid from Eastern Anatolia, Dactylorhiza chuhensis Renz&Taub. - In vitro investigations


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