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dc.contributor.authorIşik, M. and Demir, Y. and Kirici, M. and Demir, R. and Şimşek, F. and Beydemir, Ş.
dc.date.accessioned2021-04-08T12:08:59Z
dc.date.available2021-04-08T12:08:59Z
dc.date.issued2015
dc.identifier10.3109/13813455.2015.1026912
dc.identifier.issn13813455
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84938150140&doi=10.3109%2f13813455.2015.1026912&partnerID=40&md5=431d83def2c5119515a7f5e65e91c508
dc.identifier.urihttp://acikerisim.bingol.edu.tr/handle/20.500.12898/4742
dc.description.abstractAnti-epileptic drugs (AEDs) have been widely used in patients with epilepsy. This study evaluated the adverse effects of two commonly prescribed AED monotherapies, carbamazepine (CBZ) and valproic acid (VPA). The aim of this study was to evaluate the influence of these anti-epileptic drugs on paraoxonase-1 (PON-1), glutathione S-transferase (GST) and acetyl cholinesterase (AChE) activities in the serum of adult patients with epilepsy. Of the 56 epileptic adults, 28 were given valproate, and the remaining 28 were given carbamazepine. Glutathione (GSH) levels in epilepsy patients receiving anti-epileptic drug treatment were insignificantly higher compared with controls. GST activity in epilepsy patients receiving anti-epileptic drug treatment was insignificantly lower compared with controls. PON1 and AChE activity in epilepsy patients receiving anti-epileptic drug treatment was significantly lower compared with controls. PON1 and AChE activities in the serum of patients treated with carbamazepine monotherapy were lower than in patients treated with valproic acid monotherapy. © 2015 Informa UK Ltd. All rights reserved: reproduction in whole or part not permitted.
dc.language.isoEnglish
dc.sourceArchives of Physiology and Biochemistry
dc.titleChanges in the anti-oxidant system in adult epilepsy patients receiving anti-epileptic drugs


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