A bis-Lewis basic 2-aminoDMAP/prolinamide organocatalyst for application to the enantioselective synthesis of Warfarin and derivatives
Abstract
A new chiral sec-amine/amidine-base hybrid catalyst, 2-aminoDMAP/prolinamide, is reported, which is able to catalyze conjugate addition of 4-hydroxycoumarin and various benzylideneacetones, a reaction that directly gives anticoagulant Warfarin and its analogues, with good yields (70-87%) and enantioselectivities (58-72%). © 2016 Elsevier Ltd.
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84963976996&doi=10.1016%2fj.tetasy.2016.04.001&partnerID=40&md5=2524d9aa49fddbf7d3e2ec6934c71050http://acikerisim.bingol.edu.tr/handle/20.500.12898/4639
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