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dc.contributor.authorOke-Altuntas, F. and Demirtas, I. and Tufekci, A.R. and Koldas, S. and Gul, F. and Behcet, L. and Gecibesler, H.I.
dc.date.accessioned2021-04-08T12:08:31Z
dc.date.available2021-04-08T12:08:31Z
dc.date.issued2016
dc.identifier10.1111/jfbc.12238
dc.identifier.issn01458884
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84959065441&doi=10.1111%2fjfbc.12238&partnerID=40&md5=21a72159ee25278aa03996ff2093bef1
dc.identifier.urihttp://acikerisim.bingol.edu.tr/handle/20.500.12898/4626
dc.description.abstractThe aim of this study was to isolate the active components from the essential oil (EO) of Satureja boissieri and to investigate the cytotoxic effects of these components on human cervical epithelioid carcinoma (HeLa) cell line. The major components of EO were found to be p-cymene (23.15%), γ-terpinene (22.84%), thymol (18.96%) and carvacrol (21.25%) using GC-MS. The components were separated by column chromatography and p-cymene, thymol and spathulenol were isolated as pure terpenoids. The cytotoxic activity of the components was investigated using the xCELLigence system (Real Time Cell Analyzer). The pure compounds, p-cymene and thymol exhibited excellent cytotoxic effects against HeLa cell line. Practical Applications: Satureja boissieri Hausskn. ex Boiss.(Lamiaceae) is known as Catri/Kekik and used as a condiment and herbal tea in the kitchen of local people in Turkey. The genus Satureja has therapeutic properties because of its high amounts of active components such as thymol, carvacrol, p-cymene and γ-terpinene. The results demonstrated that S. boissieri and its active components may be suggested as a promising natural agents for alleviating human cervical epithelioid carcinoma cell growth. © 2016 Wiley Periodicals, Inc.
dc.language.isoEnglish
dc.sourceJournal of Food Biochemistry
dc.titleInhibitory Effects of the Active Components Isolated from Satureja Boissieri Hausskn. Ex Boiss. On Human Cervical Cancer Cell Line


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