Show simple item record

dc.contributor.authorTaslimi, P. and Kandemir, F.M. and Demir, Y. and İleritürk, M. and Temel, Y. and Caglayan, C. and Gulçin, İ.
dc.date.accessioned2021-04-08T12:06:50Z
dc.date.available2021-04-08T12:06:50Z
dc.date.issued2019
dc.identifier10.1002/jbt.22313
dc.identifier.issn10956670
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85061978851&doi=10.1002%2fjbt.22313&partnerID=40&md5=0d9c48c7d716dccae96827b8c85d9abe
dc.identifier.urihttp://acikerisim.bingol.edu.tr/handle/20.500.12898/4115
dc.description.abstractChrysin (CH) or 5,7-dihydroxyflavone is a flavonoid present in various plants, bee propolis, and honey. Cyclophosphamide (CYP) is a chemotherapeutic drug, which is extensively used in the treatment of multiple human malignancies. In our study, we aimed to investigate the effects of CYP and CH on some metabolic enzymes including carbonic anhydrase, aldose reductase, paraoxonase-1, α-glycosidase, acetylcholinesterase, and butyrylcholinesterase enzyme activities in the brain, heart, testis, liver, and kidney tissues of rats. Thirty-five adult male Wistar rats were used. The animals were pretreated with CH (25 and 50 mg/kg b.w.) for seven days before administering a single dose of CYP (200 mg/kg b.w.) on the seventh day. In all the tissues, the treatment of CH significantly regulated these enzyme activities in CYP-induced rats. These results showed that CH exhibited an ameliorative effect against CYP-induced brain, heart, liver, testis, and kidney toxicity. © 2019 Wiley Periodicals, Inc.
dc.language.isoEnglish
dc.sourceJournal of Biochemical and Molecular Toxicology
dc.titleThe antidiabetic and anticholinergic effects of chrysin on cyclophosphamide-induced multiple organ toxicity in rats: Pharmacological evaluation of some metabolic enzyme activities


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record