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dc.contributor.authorDemiroz, S. and Ur, K. and Bengu, A.S. and Ulucan, A. and Atici, Y. and Erdogan, S. and Cirakli, A. and Erdem, S.
dc.date.accessioned2021-04-08T12:06:39Z
dc.date.available2021-04-08T12:06:39Z
dc.date.issued2020
dc.identifier10.3340/jkns.2019.0178
dc.identifier.issn20053711
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85081268411&doi=10.3340%2fjkns.2019.0178&partnerID=40&md5=8a0c7ba7d942039bef2cd5009d809cea
dc.identifier.urihttp://acikerisim.bingol.edu.tr/handle/20.500.12898/4031
dc.description.abstractObjective: To evaluate the neuroprotective effects of lacosamide after experimental peripheral nerve injury in rats. Methods: A total of 28 male wistar albino rats weighing 300–350 g were divided into four groups. In group I, the sciatic nerve exposed and the surgical wound was closed without injury; in group II, peripheral nerve injuries (PNI) was performed after dissection of the nerve; in group III, PNI was performed after dissection and lacosamide was administered, and in group IV, PNI was performed after dissection and physiological saline solution was administered. At 7 days after the injury all animals were sacrificed after walking track analysis. A 5 mL blood sample was drawn for biochemical analysis, and sciatic nerve tissues were removed for histopathological examination. Results: There is low tissue damage in lacosamide treated group and antioxidant anzymes and malondialdehyde levels were higher than non-treated and placebo treated group. However there was no improvement on clinical assessment. Conclusıon: The biochemical and histological analyses revealed that lacosamide has neuroprotective effect in PNI in rats. This neuroprotective capacity depends on its scavenger role for free oxygen radicals by increasing antioxidant enzyme activity. Copyright © 2020 The Korean Neurosurgical Society.
dc.language.isoEnglish
dc.sourceJournal of Korean Neurosurgical Society
dc.titleNeuroprotective effects of lacosamide in experimental peripheral nerve injury in rats: A prospective randomized and placebo-controlled trial


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