Synthesis and spectroscopic characterizations of hexakis[(1-(4′-oxyphenyl)-3-(substituted-phenyl)prop-2-en-1-one)]cyclotriphosphazenes: their in vitro cytotoxic activity, theoretical analysis and molecular docking studies
Date
2020Author
Doğan, H. and Bahar, M.R. and Çalışkan, E. and Tekin, S. and Uslu, H. and Akman, F. and Koran, K. and Sandal, S. and Görgülü, A.O.
Metadata
Show full item recordAbstract
The hexachlorocyclotriphosphaze compound (N3P3Cl6, HCCP) was reacted with excess (E)-(1-(4′-oxyphenyl)-3-(substituted-phenyl)prop-2-en-1-ones (2-11) to produce hexakis[(1-(4-oxyphenyl)-3-(substituted-phenyl)prop-2-en-1-one)]cyclotriphosphazenes (CP 2-11). The structures of products (CP 2-11) were confirmed using elemental analysis, FT-IR, MS spectral analysis as well as 31P, 1H and 13C-APT NMR techniques and their thermal properties determined by TGA and DSC techniques. The HOMO-LUMO energy gap and chemical reactivity identifiers were calculated and HOMO and LUMO images were viewed. According to the calculations, all the chemical potential values of CP 2-11 are negative and it shown that the molecules are stable. The in vitro cytotoxic of CP 2-11 investigated and their activity potentials were evaluated by molecular docking studies with Autodock Vina softwares. CP 2-11 compounds were found to demonstrate cytotoxic activity against human cancer cell lines (A2780, LNCaP and PC-3). The CP 2-11 compounds reduced the cell viability against all cancer cell lines in the range 36%–90% especially. The results showed that these compounds are powerful candidate molecules for pharmaceutical applications. © 2020 Informa UK Limited, trading as Taylor & Francis Group.
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85096315080&doi=10.1080%2f07391102.2020.1846621&partnerID=40&md5=80f7e2d79ea1ef061fa91408bcf63e68http://acikerisim.bingol.edu.tr/handle/20.500.12898/4001
Collections
![Creative Commons License](http://i.creativecommons.org/l/by-nc-nd/4.0/88x31.png)
DSpace@BİNGÖL by Bingöl University Institutional Repository is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 Unported License..