Localized amyloid-like accumulation in a zebrafish (Danio rerio): A case report

Abstract

Amyloidosis is described as collection of extracellular proteins with a characteristic fibrillar form with electron microscopy, a typical X-ray diffraction pattern and a green reflection with Congo red affinity. Zebrafish is an appropriate model organism for studying developmental immunology for modeling many infectious disorders. We observed that localized amyloid-like deposition was in the peritoneal membrane which is showing greenish reflection in the polarized filter with Congo red staining and immuno-positive staining with primary antibody of amyloid precursor protein. Consequently, in this case report, we demonstrated that incidentally detected and rarely seen localized amyloid-like accumulation in a zebrafish. © 2020, Central Fisheries Research Inst. All rights reserved.