Basit öğe kaydını göster

Protective effect of rutin on mercuric chloride-induced reproductive damage in male rats

dc.contributor.authorKandemir, F.M. and Caglayan, C. and Aksu, E.H. and Yildirim, S. and Kucukler, S. and Gur, C. and Eser, G.
dc.date.accessioned2021-04-08T12:06:25Z
dc.date.available2021-04-08T12:06:25Z
dc.date.issued2020
dc.identifier10.1111/and.13524
dc.identifier.issn03034569
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85079036338&doi=10.1111%2fand.13524&partnerID=40&md5=5ee5b1a70a0a1fcbb14236b3593800fc
dc.identifier.urihttp://acikerisim.bingol.edu.tr/handle/20.500.12898/3917
dc.description.abstractThis study investigated the effects of rutin against reproductive damage caused by toxic mercury in male rats. Thirty-five Sprague Dawley rats were used. Control group was injected with saline for 7 days. The rutin-100 group received 100 mg/kg/b.w. rutin for 7 days. Mercuric chloride (HgCl2) group received 1.23 mg/kg/b.w. of HgCl2 for 7 days. Mercury chloride + rutin-50 group received 50 mg/kg/b.w. rutin and HgCl2 1.23 mg/kg/b.w. for 7 days. HgCl2 + rutin-100 group received 100 mg/kg/b.w. rutin and HgCl2 1.23 mg/kg/b.w. for 7 days. It was detected that HgCl2 treatment increased malondialdehyde (MDA) levels, tumour necrosis factor-α (TNF-α) and cyclooxygenase-2 (COX-2) expressions, necrosis and degeneration of spermatogonium, dead and abnormal sperm percentages; tubular walls thinning; and decreased antioxidant enzyme activities and sperm motility. It was determined that rutin application reduced testicular damage caused by HgCl2. In conclusion, rutin administration may treat HgCl2 toxicity in testes. © 2020 Blackwell Verlag GmbH
dc.language.isoEnglish
dc.sourceAndrologia
dc.titleProtective effect of rutin on mercuric chloride-induced reproductive damage in male rats


Bu öğenin dosyaları:

DosyalarBoyutBiçimGöster

Bu öğe ile ilişkili dosya yok.

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster