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dc.contributor.authorKucukler, S. and Darendelioğlu, E. and Caglayan, C. and Ayna, A. and Yıldırım, S. and Kandemir, F.M.
dc.date.accessioned2021-04-08T12:06:06Z
dc.date.available2021-04-08T12:06:06Z
dc.date.issued2020
dc.identifier10.1016/j.lfs.2020.118382
dc.identifier.issn00243205
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85090730945&doi=10.1016%2fj.lfs.2020.118382&partnerID=40&md5=f92a5f1855c94978361c72dfa24db74e
dc.identifier.urihttp://acikerisim.bingol.edu.tr/handle/20.500.12898/3844
dc.description.abstractAim: Vancomycin (VCM) is a glycopeptide antibiotic widely used to treat serious infections caused by methicillin-resistant Staphylococcus aureus and has been associated with some severe side effects such as hepatotoxicity and nephrotoxicity. However, the underlying mechanism of VCM-induced hepatotoxicity is not yet fully understood. Therefore, the current study was designed to evaluate the protective effects of zingerone (Zin) against VCM-induced hepatotoxicity in rats. Materials and methods: VCM was intraperitoneally administered at a dose of 200 mg/kg body weight (b.w.) for 7 days alone and in combination with the orally administered Zin (25 and 50 mg/kg b.w). Key findings: Zin treatment significantly improved VCM-induced hepatic lipid peroxidation, glutathione depletion, reduced antioxidant enzyme (superoxide dismutase, catalase and glutathione peroxidase) activities and liver function markers (aspartate aminotransferase, alkaline phosphatase and alanine aminotransferase). Histopathological integrity and immunohistochemical expression of 8-hydroxy-2′-deoxyguanosine (8-OHdG) in the VCM-induced liver tissue were ameliorated after Zin administration. In addition, Zin reversed the changes in levels and/or activities of inflammatory and apoptotic parameters such as nuclear factor kappa B (NF-κB), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), p53, cysteine aspartate specific protease-3 (caspase-3), cysteine aspartate specific protease-8 (caspase-8), cytochrome c, Bcl-2 associated X protein (Bax) and B-cell lymphoma-2 (Bcl-2) in the VCM-induced hepatotoxicity. Significance: Collectively, these results reveal probable ameliorative role of Zin against VCM-induced hepatotoxicity. © 2020
dc.language.isoEnglish
dc.sourceLife Sciences
dc.titleZingerone attenuates vancomycin-induced hepatotoxicity in rats through regulation of oxidative stress, inflammation and apoptosis


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