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dc.contributor.authorGecibesler, I.H. and Disli, F. and Bayindir, S. and Toprak, M. and Tufekci, A.R. and Sahin Yaglıoglu, A. and Altun, M. and Kocak, A. and Demirtas, I. and Adem, S.
dc.date.accessioned2021-04-08T12:05:57Z
dc.date.available2021-04-08T12:05:57Z
dc.date.issued2021
dc.identifier10.1016/j.foodchem.2020.128378
dc.identifier.issn03088146
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85093087716&doi=10.1016%2fj.foodchem.2020.128378&partnerID=40&md5=b1d47210e04567822543f8eae56dddcb
dc.identifier.urihttp://acikerisim.bingol.edu.tr/handle/20.500.12898/3758
dc.description.abstractRheum ribes L. (Rhubarb) is one of the most important edible medicinal plants in the Eastern Anatolia region and is called “Işkın” by local people. Resveratrol and 6-O-methylalaternin were isolated from the Rhubarb for the first time in addition to well-known secondary metabolites including emodin, aloe-emodin, β-sitosterol and rutin. The new semi-synthetic anthraquinone derivatives with the NαFmoc-L-Lys and ethynyl group were synthesized from the isolated anthraquinones emodin and aloe-emodin of Rhubarb to increase the bioactivities. Aloe-emodin derivative with NαFmoc-L-Lys shows the highest inhibition values by 94.11 ± 0.12 and 82.38 ± 0.00% against HT-29 and HeLa cell lines, respectively, at 25 µg/mL. Further, modification of the aloe-emodin with both the ethynyl and the NαFmoc-L-Lys groups showed an antioxidant activity-enhancing effect. From molecular docking studies, the relative binding energies of the emodin and aloe-emodin derivatives to human serum albumin ranged from −7.30 and −10.62 kcal/mol. © 2020 Elsevier Ltd
dc.language.isoEnglish
dc.sourceFood Chemistry
dc.titleThe isolation of secondary metabolites from Rheum ribes L. and the synthesis of new semi-synthetic anthraquinones: Isolation, synthesis and biological activity


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