The isolation of secondary metabolites from Rheum ribes L. and the synthesis of new semi-synthetic anthraquinones: Isolation, synthesis and biological activity
Tarih
2021Yazar
Gecibesler, I.H. and Disli, F. and Bayindir, S. and Toprak, M. and Tufekci, A.R. and Sahin Yaglıoglu, A. and Altun, M. and Kocak, A. and Demirtas, I. and Adem, S.
Üst veri
Tüm öğe kaydını gösterÖzet
Rheum ribes L. (Rhubarb) is one of the most important edible medicinal plants in the Eastern Anatolia region and is called “Işkın” by local people. Resveratrol and 6-O-methylalaternin were isolated from the Rhubarb for the first time in addition to well-known secondary metabolites including emodin, aloe-emodin, β-sitosterol and rutin. The new semi-synthetic anthraquinone derivatives with the NαFmoc-L-Lys and ethynyl group were synthesized from the isolated anthraquinones emodin and aloe-emodin of Rhubarb to increase the bioactivities. Aloe-emodin derivative with NαFmoc-L-Lys shows the highest inhibition values by 94.11 ± 0.12 and 82.38 ± 0.00% against HT-29 and HeLa cell lines, respectively, at 25 µg/mL. Further, modification of the aloe-emodin with both the ethynyl and the NαFmoc-L-Lys groups showed an antioxidant activity-enhancing effect. From molecular docking studies, the relative binding energies of the emodin and aloe-emodin derivatives to human serum albumin ranged from −7.30 and −10.62 kcal/mol. © 2020 Elsevier Ltd
Bağlantı
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85093087716&doi=10.1016%2fj.foodchem.2020.128378&partnerID=40&md5=b1d47210e04567822543f8eae56dddcbhttp://acikerisim.bingol.edu.tr/handle/20.500.12898/3758
Koleksiyonlar
![Creative Commons License](http://i.creativecommons.org/l/by-nc-nd/4.0/88x31.png)
DSpace@BİNGÖL by Bingöl University Institutional Repository is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 Unported License..