THE EFFECTS OF HYDROXYUREA DERIVATIVE 1, 3, 4-THIADIAZOLES ON SERUM BIOCHEMICAL PARAMETERS AND ANTIOXIDANT STATUS IN LIVER OF RATS
Date
2013Author
Karagozoglu, Yusuf and Turkoglu, Semra and Parlak, Akif E. and Alayunt,
Naci O.
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In this study, it was aimed to investigate the antioxidant and
antihepatotoxic effect of hydoxyurea derivative 1,3,4-thiadiazoles on
serum biochemical parameters (AST, ALT, LDH, urea, creatinine and total
bilirubin) and antioxidant parameters (SOD, CAT, GPX, MDA). In our
study, a total of 35 adult male wistar rats were divided into 5 equal
groups. DMSO diluted with only corn oil, was injected to the control
group. 25 mg/kg ligand, 25 mg/kg thiadiazole-manganese, 25 mg/kg
thiadiazole-cadmium and 25 mg/kg thiadiazole-chrome complexes was
injected to the experimental groups rats subcutaneously for 15 days with
three-day interval during the test. After blood samples were centrifuged
AST, ALT, LDH enzyme activites hepatic injury; and then, the activites
of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase
(GPX), and the level of malondialdehyde (MDA) in liver tissues were
determined spectrophotometrically. The level of AST was found to be
lower (p<0.05) in the Cr-L group than in other groups. The levels of ALT
and total bilirubine were found to be lower (p<0.05) in the Cd-L group
than in other groups. The level of SOD was found to be higher (p<0.05)
in the Cd-L group than in other groups. The levels of GPX was found to
be lower (p<0.05) in the Cr-L group than in other groups. As a result,
it can be concluded that their pharmacological characteristics can be
beneficial in many fields of application because hydroxyurea derivative
1,3,4 thiadiazole compounds show the antioxidant and antihepatotoxic
activity.
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