THE EFFECTS HYDROXYUREA DERIVATIVE SCHIFF BASES ON FATTY ACIDS AND LYPOPHILIC VITAMINS IN LIVER OF RATS
Date
2014Author
Turkoglu, Semra and Parlak, Akif E. and Yildirim, Isil and Karagozoglu,
Yusuf and Alayunt, Naci O.
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Schiff bases and their metal complexes have antiviral, antimicrobial,
antitumoral, radical scavenging and antioxidant activities. In this
study, effects of Schiff base ligand and its metal complexes on the
fatty acids and lyphophlilic vitamins of the liver of rats were
investigated. The fatty acids of the liver were determined by GC and
lyphophlilic vitamins of the liver determined by HPLC. The amounts of
stearic acid (18:0), oleic acid (18:1) and monounsaturated fatty acids
(MUFA) considerably decreased in the Mn, Ni and Zn complexes groups,
whereas the amount of linolenic acid (18:3) and eicosatrienoic acid
(20:3) considerably increased in the Ni an Zn complexes groups compared
to the control group (P<0.01). However, there was no significant
difference (P>0.05) in the amounts of arachidonic acid (20:4),
docosahexaenoic acid (22:6), total saturated fatty acids (SFA) and
polyunsaturated fatty acids (PUFA), total omega-3 and omega-6 fatty
acids between groups. The amounts of vitamin K-1, vitamin D-2
considerably increased (P<0.05) in the Mn and Ni complexes groups as
compared to the control. It was observed that the amount of a-tocopherol
increased both in the Ni and Co complexes groups when compared to the
control group but this increase was parallel to the amount in the same
groups (P<0.05). As a result, it can be think that with the application
of toxic metals such as manganese, cupper, nickel, cobalt, and zinc
unsaturated fatty acids affected the activities of enzymes which are in
the liver tissue and in charge in the fatty acid chain elongation.
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