Designing an Intracellular Fluorescent Probe for Glutathione: Two
Modulation Sites for Selective Signal Transduction

dc.contributor.author	Isik, Murat and Guliyev, Ruslan and Kolemen, Safacan and Altay, Yigit and Senturk, Berna and Tekinay, Turgay and Akkaya, Engin U.
dc.date.accessioned	2021-04-02T12:03:51Z
dc.date.available	2021-04-02T12:03:51Z
dc.date.issued	2014
dc.identifier	10.1021/ol501272z
dc.identifier.issn	1523-7060
dc.identifier.uri	http://acikerisim.bingol.edu.tr/handle/20.500.12898/2592
dc.description.abstract	A selective probe for glutathione was designed and synthesized. The design incorporates spatial and photophysical constraints for the maximal emission signal. Thus, pHs, as well as the intracellular thiol concentrations, determine the emission signal intensity through a tight control of charge-transfer and PeT processes. The probe works satisfactorily inside the human breast adenocarcinoma cells, highlighting GSH distribution in the cytosol.
dc.language.iso	English
dc.source	ORGANIC LETTERS
dc.title	Designing an Intracellular Fluorescent Probe for Glutathione: Two Modulation Sites for Selective Signal Transduction
dc.type	Article

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