The effect of graft application and simvastatin treatment on tibial bone defect in rats. A histological and immunohistochemical study
Tarih
2019Yazar
Lacin, Nihat and Izol, Bozan Serhat and Ozkorkmaz, Ebru Gokalp and
Deveci, Busra and Tuncer, Mehmet Cudi
Üst veri
Tüm öğe kaydını gösterÖzet
Purpose: To evaluate histologically and immunohistochemically the bone
regeneration after application of simvastatin on tibial bone defects in
rats.
Methods: Sixty Wistar albino rats were divided into 3 groups as control
(6 mm tibial bone defect), defect + graft (allograft treatment), and
defect + graft + simvastatin (10 mg/kg/day) for 28 days.
Results: Histopathological examination revealed inflammation in control
group (defect group), congestion in blood vessels, and an increase in
osteoclast cells. In defect + graft group, osteoclastic activity was
observed and osteocyte cells were continued to develop. In defect +
graft + simvastatin group, osteocytes and matrix formation were
increased in the new bone trabeculae. Osteopontin and osteonectin
expression were positive in the osteclast cells in the control group.
Osteoblasts and some osteocytes showed a positive reaction of
osteopontin and osteopontin. In defect + graft + simvastatin group,
osteonectin and osteopontin expression were positive in osteoblast and
osteocyte cells, and a positive expression in osteon formation was also
seen in new bone trabeculae.
Conclusion: The simvastatin application was thought to increase bone
turnover by increasing the osteoinductive effect with graft and
significantly affect the formation of new bone.
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