https://acikerisim.bingol.edu.tr/handle/20.500.12898/1215 Biology Tue, 07 Apr 2026 15:15:35 GMT 2026-04-07T15:15:35Z https://acikerisim.bingol.edu.tr/handle/20.500.12898/1072 Pistacia eurycarpa Inhibits Cell Proliferation and Induces Apoptosis in Colorectal Cancer by Modulating Apoptotic Pathway Genes Erdoğan, Mehmet Kadir; Ağca, Can Ali; Aşkın, Hakan Colorectal cancer (CRC) is the third most common cancer. Its global incidence and mortality have been on the rise. Recent strategy of therapies has involved the use of non-steroid anti-inflammatory drugs and cyclooxygenase-selective inhibitors. The genus Pistacia consists of small trees of the cashew nut family Anacardiaceae and is native to tropical and subtropical Asia where its members have long been cultivated for a variety of uses. The trunk of Pistacia species produces a characteristic exudate called mastic gum. The mastic gum and oil are medicinally used against rabies, snake bites, baldness, scabies, as well as in prescriptions for stomach, intestine, bladder, and liver inflammations, oral and dental diseases. In this study, growth-inhibiting and pro-apoptotic effects of hexane, chloroform and methanol extracts of Pistacia eurycarpa in HT-29 colorectal cancer cell line were investigated. Wed, 04 May 2016 00:00:00 GMT https://acikerisim.bingol.edu.tr/handle/20.500.12898/1072 2016-05-04T00:00:00Z https://acikerisim.bingol.edu.tr/handle/20.500.12898/1066 Essential Oil Composition and Antioxidant Activity of Saponaria prostrata WILLD. subsp. anatolica HEDGE ERDOĞAN, Mehmet Kadir; Geçibesler, İbrahim Halil; Behçet, Lütfi In this study, we investigated the chemical composition and antioxidant activity of the essential oil of Saponaria prostrata WILLD. subsp. anatolica HEDGE. The essential oil of plant was obtained by hydrodistillation method and analyzed by HS-SPME/GC-MS. Thirty nine compounds were identified, which representing 91.77% of the oil. Among them Palmitic acid (36.53%), Pentanal (17.38%), 2-Pentadecanone, 6,10,14-trimethyl (9.68%), 2,6,10-Trimethyl,14-Ethylene-14-Pentadecne (5.96%) and 1,8-Diazacyclotetradecane-2,9-dion (4.64%) were the major compounds. The antioxidant capacity of S. prostrata subsp. anatolica was evaluated by different methods and results were compared with BHA, BHT, vit.E, vit. C, EDTA and trolox. Sat, 19 Mar 2016 00:00:00 GMT https://acikerisim.bingol.edu.tr/handle/20.500.12898/1066 2016-03-19T00:00:00Z https://acikerisim.bingol.edu.tr/handle/20.500.12898/1059 Synergistic Effects of Achillea biebersteinii and 5-FU Against Colorectal Cancer Cells Erdoğan, Mehmet Kadir; Ağca, Can Ali; Aşkın, Hakan Colorectal cancer (CRC) is a major reason of cancer-related death, approximately 1.2 million new cases are reported each year in the worldwide and more than half die from the disease. 5-Fluorouracil (5-FU) is the backbone in the clinical treatment of advanced CRC. However, beside the antitumor effect most toxicities attributed to the drug and observed severe side effects. Therefore, novel treatments are still needed. 5-FU-based chemotherapeutic regimens are established as a fundamental standart treatment for metastatic colorectal cancer. Antimicrobial, antioxidant, antiinflammatory, spasmolytic, antidiabetic, antiulcer, antitumor, choleretic and hepatoprotective activity, and cytotoxic effects of different Achillea species have been previously reported. A. biebersteinii Afan. (Asteraceae) is a perennial herb, villose, stems erect, simple or branched from the base; 30–60 cm high; leaves up to 10 cm; flowering period, April-May. In this study, antiproliferative and apoptotic effects of A. biebersteinii and it’s combination with 5-FU were analyzed with various methods. Wed, 04 May 2016 00:00:00 GMT https://acikerisim.bingol.edu.tr/handle/20.500.12898/1059 2016-05-04T00:00:00Z