https://acikerisim.bingol.edu.tr/handle/20.500.12898/1210 Faculty of Health Sciences 2026-04-20T10:08:32Z https://acikerisim.bingol.edu.tr/handle/20.500.12898/1144 Genç Yetişkinlerde Pasif Sigara Maruziyetinin Diyet Kalitesine, Oksidatif Stres İndeksine ve Beslenme Durumuna Etkisi Erçim, Rüveyda Esra; Baydaş, Burhanettin Amaç: Bu araştırma, pasif sigara maruziyetinin genç bireylerin diyet kalitesine, oksidatif stres indeksine ve beslenme durumuna etkisinin olup olmadığının belirlenmesi amacıyla planlanıp yürütülmüştür. Gereç ve Yöntem: Bingöl’de 19-35 yaş arasındaki 40 birey ile gerçekleştirilen çalışma, kesitsel bir vaka-kontrol çalışmasıdır. Katılımcılar; sigara içmeyip, içilen ortamda dumanına maruz kalanlar (pasif sigara içicileri) ile hiç sigara içmemiş ve dumanına maruz kalmamış bireyler olmak üzere iki gruba ayrılmıştır. Soru kâğıdı ile katılımcıların 7 gün boyunca 24 saatlik besin tüketim kaydı alınmış; Besin Çeşitlilik Skoru (DDS), Diyet Kalite indeksi (DQI) ve sağlıklı yeme indeksi (HEI-2005) hesaplanmıştır. Katılımcıların Uluslararası Fiziksel Aktivite Anketinin (IPAQ) kısa formu ile fiziksel aktivite düzeyi saptanmıştır. Serum örneklerinden katılımcıların serum total antioksidan kapasitesi (TAC) ve toplam oksidan durumu (TOS) analiz edilip Oksidatif Stres İndeksi (OSİ) saptanmıştır. İstatistiki verilerin hesaplanmasında, SPSS 22.0 paket programı kullanılmıştır. Bulgular: Katılımcıların yaş ortalaması erkeklerde 21.7±1.5 ve kadınlarda 20.3±0.8 yıldır. Çalışma gruplarına göre katılımcıların diyetle alınan enerjinin proteinden gelen oranı, PUFA (çoklu doymamış yağ asidi), A vitamini, E vitamini ve B12 vitamini dışında kalan diğer enerji ve besin ögeleri gruplar arasında istatistiksel olarak farklı bulunmuştur (P<0.05). Sigaraya maruz kalan katılımcıların enerji, protein, karbonhidrat, yağ, posa gibi birçok besin ögesi alımları kontrol grubundan düşük olduğu görülmüştür. Serum TAC enzim aktiviteleri açısından gruplar arasında anlamlı fark bulunmazken (P>0.05), TOS ve OSİ değerleri pasif grupta fazla bulunmuştur (P<0.05). Sonuç: Hastalıkların önlenmesi ve sağlığın geliştirilmesi açısından, bireylerin sigara dumanına maruziyetinin önlenmesi ve fiziksel aktivite ve sağlıklı beslenmenin desteklenmesiyle önlenebilir hastalıklar başta olmak üzere özellikle yaşlılık döneminde ortaya çıkabilecek hastalıklardan korunmada etkili olacaktır. Bingöl Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi tarafından (Numara: BAP-80-326-2015) desteklenmiştir. 2017-10-01T00:00:00Z https://acikerisim.bingol.edu.tr/handle/20.500.12898/822 Anti-radical Flavonoids from Teucrium chamaedrys L. subsp. sinuatum (Celak.) Rech. F. Geçibesler, İbrahim Halil Teucrium species are aromatic plants with interesting pharmacological and biological properties. A phytochemical investigation of the aerial parts Teucrium chamaedrys L. subsp. sinuatum led to the isolation of a flavone named 5,6,3'-trihydroxy-7,4'-dimethoxyflavone (1) and a flavone glycoside, luteolin-7-O-glucoside (2) from the polar extract. Both compounds were isolated and identified for the first time in Teucrium chamaedrys L. subsp. sinuatum. In vitro anti-radical activity of both the compounds was assessed by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay. Compound 1 triggered a significant decrease in amount of DPPH radicals with EC50 value of 43.41± 2.17 μg/ml. 2016-03-19T00:00:00Z https://acikerisim.bingol.edu.tr/handle/20.500.12898/821 Antioxidant Activity and Phenolic Content of Different Parts of Chrysophthalmum montanum (DC.) Boiss. Geçibesler, İbrahim Halil Natural antioxidants with plant-origin have been used for years in the food, medical and cosmetics applications as well as folk medicine due to their effective ingredients against various pathogenic cases. For these reason, this study reports the antioxidant activities of methanolic extracts from flower (CF), stem (CS), root (CR) and leaf (CL) of Chrysophthalmum montanum from Turkey and determination their antioxidant contents in terms of total phenolic and flavonoid. The antioxidative activities were measured using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging test, 2,2'-azinobis[3-ethylbenzthiazoline-6-sulphonic acid (ABTS) assay, superoxide anion scavenging activity (SASA) assay, lipid peroxidation test with ferric thiocyanate (FTC) method, reducing power activity (RPA) assay and metal-ion chelating power (MCP). The in vitro experiments revealed that CF extract could decrease the production of ROS and free radicals in media as much as positive standards. The findings mean that title plant is highly important in antioxidant activities. It was suggested that phenolic and flavonoid components might contribute its antioxidant activities against free radicals. This study will bring an innovation for further studies on the antioxidant properties of C. montanum and especially the CF extract can be considered as a source of potential antioxidants and it would promote the reasonable usage of this plant in food technology and processing as well as for medical use. 2016-03-19T00:00:00Z https://acikerisim.bingol.edu.tr/handle/20.500.12898/820 Comparative assessment of phenolic and flavonoid contents of some Citrus peels and their antioxidant capacity Geçibesler, İbrahim Halil Aim of the study: To determine the richest phenolic and flavonoid content of fresh, dried and frozen of some highly economic citrus peels mandarin (Citrus reticulata), orange (Citrus sinensis), lemon (Citrus limon) and grapefruit (Citrus paradisi) as well as antioxidant capacities. Material and Methods: Ultrasound assisted extraction was used to recover extracts from fresh, frozen and dried Citrus peels. The antioxidant activity studies were carried out by 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radicals, superoxide anion radicals, reducing power, metal-ion chelating and total antioxidant activity by ferric thiocyanate methods. The total phenolic content (Folin–Ciocalteu assay) and flavonoid content were also determined by UV-VIS spectrometer. Results: Fresh, frozen and dried citrus peels showed good antioxidant activity in all the biological antioxidant activity experiments (p<0.05). The total phenolic content ranged from 67.36±3.09 to 227.21±1.78 mg of gallic acid equivalents (GAE)/100 g dry extract. Interestingly, among citrus samples, dried lemon and grapefruit had the highest total phenolic contents of 168.34±4.03 and 227.21±1.78 mg (GAE)/100 g dry extract, respectively. At the concentration of 75 μg/ml, dried lemon extract exhibited the highest superoxide anion radical scavenging and reducing power activities with scavenging percentage of 93.45 and 88.81 %, respectively, however, at same concentration, the superoxide anion radical scavenging and reducing power activities of dried orange extract were 68.54 and 71.59%, respectively . These results showed that the amounts of phenolics compounds were in accordance with higher effectiveness in performed antioxidant activity tests. Acknowledgements: The author thanks for financial support the projects of Scientific Research Project Department of Bingol University (Projects No: BAP-21-217-2014 and BAP-21-322-2015). 2016-05-23T00:00:00Z